Ivermectin
Ivermectin
Ivermectin ni ifu yera ya kristaline, impumuro nziza.Irashobora gushonga kubuntu muri methanol, Ethanol, acetone, Ethyl acetate, muburyo budashobora gushonga mumazi, hamwe na hygroscopique.Ivermectin ni semisintetike ya macrolide ya antibiyotike igizwe nibice byinshi, irimo cyane cyane ivermectin B1 (Bla + B1b) ibirimo munsi ya 95%, muri byo Bla ikaba itari munsi ya 85%.
Ihame ry'ubuvuzi
Ivermectin igira ingaruka zo guhitamo, muguhuza cyane cyane imiyoboro ya chloride hamwe na glutamate nka valve mumyanya myakura ningirangingo yimitsi yinyamaswa zidafite izunguruka, ibyo bigatuma habaho kwinjirira mumyanya ndangagitsina kuri ion ya chloride, bitera hyperpolarisation ya selile nervice. cyangwa ingirangingo z'imitsi, kandi itera ubumuga cyangwa urupfu rwa parasite.Ihuza kandi n'imiyoboro ya chloride yandi marenga ya ligand, nka acide neurotransmitter g-aminobutyric aside (GABA).Guhitamo ibicuruzwa ni ukubera ko inyamaswa z’inyamabere zimwe na zimwe zidafite imiyoboro ya glutamate-chloride muri vivo, kandi avermectin ifitanye isano rito gusa n’imiyoboro y’inyamabere ya ligand-chloride.Iki gicuruzwa ntigishobora gucengera inzitizi yamaraso yubwonko bwabantu.Onchocerciasis na strongyloidiasis na hookworm, ascaris, Trichuris trichiura, na Enterobius vermicularis.
Gukoresha
Ivermectin ni imiti ikoreshwa mu kuvura ubwoko bwinshi bwa parasite.Ivermectin ikoreshwa mu kuvura indwara zinyamaswa ziterwa ninzoka zangiza na ectoparasite.
Ivermectin isanzwe ikoreshwa muguhashya inyo za parasitike mu nzira ya gastrointestinal yinyamanswa.Izi parasite mubisanzwe zinjira mu nyamaswa iyo zirisha, zinyura mu mara, hanyuma zigashyira kandi zikuze mu mara, nyuma zikabyara amagi asiga inyamaswa akoresheje ibitonyanga kandi ashobora gutera urwuri rushya.Ivermectin ifite akamaro mukwica bamwe, ariko sibyose, murizo parasite.Mu mbwa ikoreshwa bisanzwe nka prophylaxis irwanya umutima.
Mubuvuzi bwamatungo, bukoreshwa mukurinda no kuvura indwara yumutima na acariasis, mubindi bimenyetso.Irashobora gufatwa numunwa cyangwa igashyirwa kuruhu kugirango yanduze hanze.Ivermectin ikoreshwa cyane kuri nematode ya gastrointestinal, inzoka zo mu bihaha, na arthropods ya parasitike mu nka, intama, amafarasi, n'ingurube, nematode yo mu nda mu mbwa, miti y'amatwi, Sarcoptes scabiei, umutima filariae, na microfilariae, na gastrointestinal nematode na ectoparasite.
Imyiteguro
Gutera Ivermectin1%, 2%, 3.4%, 4%;
Ivermectin umunwa igisubizo 0.08%, 0.8%, 0.2%;
Ivermectin;
Ivermectin bolus;
Ivermectin isuka kumuti 0.5%, 1%;
Ivermectin gel 0.4%
Inzobere mu bya tekinike yabigize umwuga yitangiye kukuyobora
Ukurikije ibyo ukeneye mubyukuri, hitamo uburyo bushyize mu gaciro bwo gutegura no gutegura