Pharmacodynamics

Amoxicillin ndi mankhwala a β-lactam okhala ndi antibacterial effect.Mphamvu ya antibacterial ndi antibacterial zochita ndizofanana ndi za ampicillin, ndipo antibacterial zochita motsutsana ndi mabakiteriya ambiri a Gram-positive ndi ofooka pang'ono kuposa penicillin.Zimakhudza kwambiri mabakiteriya a Gram-negative monga Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella ndi Pasteurella, koma mabakiteriyawa amatha kukana mankhwala.Osatengeka ndi Pseudomonas aeruginosa.Chifukwa mayamwidwe ake mu nyama ya monogastric ndiabwino kuposa ampicillin ndipo kuchuluka kwake m'magazi ndikokwera, kumathandizira kuchiritsa matenda amtundu uliwonse.Ndi oyenera matenda zokhudza zonse monga kupuma dongosolo, mkodzo dongosolo, khungu ndi zofewa minofu chifukwa cha mabakiteriya tcheru.

Pharmacokinetics

Amoxicillin imakhala yokhazikika ku chapamimba acid, ndipo 74% mpaka 92% imatengedwa pambuyo pakamwa pa nyama imodzi.Nkhani za m`mimba thirakiti zimakhudza mlingo wa mayamwidwe, koma osati mlingo wa mayamwidwe, kotero akhoza kuperekedwa mu wosakaniza kudya.Mutamwa mlingo womwewo pakamwa, kuchuluka kwa amoxicillin mu seramu yamagazi kumakhala 1.5 mpaka 3 kuposa ampicillin.

(1) Kuphatikiza kwa mankhwalawa ndi aminoglycosides kumatha kuonjezera kuchuluka kwa mabakiteriya, kuwonetsa mphamvu ya synergistic.(2) Mankhwala opha tizilombo toyambitsa matenda monga macrolides, tetracyclines ndi amide alcohols amasokoneza mphamvu ya bactericidal ya mankhwalawa, ndipo sayenera kugwiritsidwa ntchito pamodzi.

β-lactam mankhwala.Pochiza matenda a amoxicillin-gram-positive ndi gram-negative mu nkhuku.

Kutengera ndi mankhwalawa.M`kamwa makonzedwe: 1 mlingo, pa 1kg thupi, nkhuku 0.2-0.3g, kawiri pa tsiku, kwa masiku 5;chakumwa chosakaniza: pa 1L madzi, nkhuku 0,6g, kwa masiku 3-5.

Iwo ali amphamvu kusokoneza kwambiri yachibadwa zomera za m`mimba thirakiti.

(1) Ndikoletsedwa kuyika nkhuku pa nthawi yoikira.

(2) Matenda a bakiteriya a gram-positive osamva penicillin sayenera kugwiritsidwa ntchito.

(3) Kugawa ndi kugwiritsa ntchito panopa.

7 masiku nkhuku.

shading, kusungidwa kosindikizidwa