Pharmacodynamics

Amoxicillin ndeye β-lactam inorwisa mabhakitiriya ine yakafara-spectrum antibacterial effect.Iyo antibacterial spectrum uye antibacterial chiitiko chakafanana neampicillin, uye antibacterial chiitiko kurwisa mabhakitiriya mazhinji eGram-positive ishoma pane iyo yepenicillin.Iine simba rakasimba pamabhakitiriya eGram-negative akadai seEscherichia coli, Proteus, Salmonella, Haemophilus, Brucella nePasteurella, asi mabhakitiriya aya anowanzoita zvinodhaka.Haisi kubatwa nePseudomonas aeruginosa.Nekuti kunyudzwa kwayo mumhuka dzemonogastric kuri nani pane iyo yeampicillin uye kuwanda kwayo muropa kwakakwira, ine kurapa kurinani pahutachiona hwe systemic.Inokodzera hutachiona hwehurongwa hwakadai sekufema system, urinary system, ganda uye zvinyoro zvinyoro zvinokonzerwa nehutachiona hwehutachiona.

Pharmacokinetics

Amoxicillin yakanyatsogadzikana kune gastric acid, uye 74% kusvika 92% inotorwa mushure mekutonga nemuromo mune monogastric mhuka.Zviri mukati megumbo remuviri zvinokanganisa chiyero chekunyura, asi kwete dhigirii yekunyura, saka inogona kupihwa mukusanganiswa kwekudya.Mushure mekutora muyero mumwechete nemuromo, iyo serum yeamoxicillin yakakwira 1.5 kusvika 3 yakakwira kupfuura iyo ampicillin.

(1) Kusanganiswa kwechigadzirwa ichi neaminoglycosides kunogona kuwedzera kuwanda kweiyo yekupedzisira mubhakitiriya, ichiratidza synergistic mhedzisiro.(2) Kukurumidza-kuita bacteriostatic agents zvakadai semacrolides, tetracyclines uye amide alcohols zvinokanganisa maitiro ebhakitiriya echigadzirwa ichi, uye haafaniri kushandiswa pamwe chete.

β-lactam antibiotics.Kurapa kweamoxicillin-inobatwa gram-positive uye gram-negative zvirwere muhuku.

Kubva pachigadzirwa ichi.Oral administration: imwe dhizimusi, pa1kg uremu hwemuviri, huku 0.2-0.3g, kaviri pazuva, kwemazuva mashanu;chinwiwa chakavhenganiswa: pa 1L yemvura, huku 0.6g, kwemazuva 3-5.

Iine simba rinopindira rinokanganisa pane yakajairika flora yemudumbu.

(1) Hakubvumidzwi pakukandira huku panguva yekukandira.

(2) Gram-positive bacterial infection inopikisa penicillin haifaniri kushandiswa.

(3) Ikozvino kugoverwa uye kushandiswa.

7 days dzehuku.

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