Kwalite usoro mmepe ọgwụ

Okwu mmalite

Dabere na teknụzụ na ọrụ ọgbara ọhụrụ

Nkọwa ngwaahịa

Mkpado ngwaahịa

Ozi izugbe

Ezubere Pọtụfoliyo nke klaasị mbụ na nke kacha mma iji gboo mkpa ahụike na-egbochaghị mkpa site na mmepe nke mono na ụdị ọgwụgwọ protein pụrụ iche, conjugates ọgwụ mgbochi mmadụ na ihe na-akpali akpali maka ndị ọrịa n'ụwa niile.

Akụkọ ihe mere eme

Nchoputa nke teknụzụ monoclonal antibody (mAb) nke Kohler na Milstein mere na 1975 nyere ohere nke ịmepụta ọgwụ mgbochi ọrịa dịka klas nke ọgwụgwọ (Kohler & Milstein, 1975).Ọgwụ mgbochi Monoclonal (mAbs) bụ otu n'ime nyiwe ọgwụ a na-ejikarị eme ihe maka ọrịa na-efe efe ma ọ bụ ọgwụgwọ ọrịa kansa n'ihi na ha na-ahọrọ ndị na-efe efe, mkpụrụ ndụ na-efe efe, mkpụrụ ndụ kansa na ọbụna sel ndị na-alụso ọrịa ọgụ.N'ụzọ dị otú a, ha na-edozi mkpochapụ nke ụmụ irighiri ihe na sel ndị nwere mmetụta dị ole na ole karịa usoro ọgwụgwọ ndị ọzọ.Karịsịa, mAbs ọgwụgwọ ọrịa kansa nwere ike ịmata protein dị n'elu cell na mkpụrụ ndụ ebumnuche wee gbuo mkpụrụ ndụ ezubere iche site na ọtụtụ usoro.
Ịmepụta mmadụ na-ebelata nke ukwuu immunogenicity ọgwụ mgbochi ọrịa n'ime mmadụ, na-eme ka nchịkwa na-adịghị ala ala kwe omume.Ọganihu dị otú ahụ na teknụzụ mgbochi mmadụ ebutela mgbawa na mmepe nke mAbs ọgwụgwọ n'ime afọ iri gara aga.A na-emepụtakwa usoro nke mgbochi mmadụ, nke gụnyere protein Fc-fusion, conjugates antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), na antibody-enzyme fusions, na-emepụta ma na-ere ahịa dị ka ọgwụgwọ ọhụrụ.

Mmetụta ọgwụ ọjọọ

Maka ndị ọrịa, ọgwụ ọhụrụ ezubere iche pụtara mmetụta dị ntakịrị, ụlọ ọgwụ ole na ole, ndụ ndụ ka mma, mmụba arụpụtaghị ihe, yana ihe dị mkpa, ogologo ndụ.Ma mmepe ọgwụ bụ ogologo usoro dị mgbagwoju anya.

Ntụaka

Kohler G, Milstein C. Omenala na-aga n'ihu nke mkpụrụ ndụ jikọtara ọnụ na-ezochi ihe mgbochi nke nkọwapụta akọwapụtara.Ọdịdị.1975;256:495–497 .doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.The therapeutic monoclonal antibody market.MAbs.2015;7:9–14 .doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-ọgwụ conjugates dị ka akwụkwọ akụkọ mgbochi ọrịa cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Ebipụtara 2015 Jul 14. Dị na https://pubmed.ncbi.nlm.nih.gov/26182432/.Enwetara July 2020.
Reichert, JM, na Valge-Archer, VE (2007).Usoro mmepe maka ọgwụgwọ ọrịa kansa monoclonal antibody.Nat Rev Drug Discov 6, 349–356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Ndịiche Fc antibody emepụtara nwere arụ ọrụ mmetụta emelitere.PNAS 103, 4005–4010.


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