Kurudzira Mafambisirwo Ezvinodhaka
General Information
first-in-class uye best-in-class portfolio yakagadzirirwa kugadzirisa zvidikanwi zvisingagoneki zvekurapa kuburikidza nekuvandudzwa kwemono uye bi-specific protein therapeutics, antibody drug conjugates uye macrophage stimulating agents kuvarwere pasi rose.
Nhoroondo
Kuwanikwa kwepasi-pasi kwehunyanzvi hwemonoclonal antibody (mAb) naKohler naMilstein muna 1975 kwakapa mukana wekugadzira masoja ekudzivirira chirwere sekirasi yekurapa (Kohler & Milstein, 1975).Monoclonal antibodies (mAbs) ndeimwe yeanonyanya kushandiswa zvinodhaka mapuratifomu ezvirwere zvinotapukira kana kenza kurapwa nekuti ivo vanosarudza kurwisa zvirwere, masero anotapukira, masero egomarara, uye kunyange masero edziviriro.Nenzira iyi, vanoyananisa kubviswa kwemamorekuru anotariswa uye maseru ane mashoma mhedzisiro pane mamwe maitiro ekurapa.Kunyanya, cancer kurapa mAbs inogona kuziva maseru-epamusoro mapuroteni pane anonangwa maseru uye obva auraya maseru anonangwa nenzira dzakawanda.
Kusarudzika kwevanhu kunoderedza zvakanyanya kurapa kweanorwisa immunogenicity muvanhu, zvichiita kuti kutonga kusingagumi kugoneke.Kufambira mberi kwakadai mumaantibody matekinoroji kwakonzera kuputika mukugadzirwa kwerapeutic mAbs mumakore gumi apfuura.Nhepfenyuro yezvinobvamo zveantibody, izvo zvinosanganisira Fc-fusion mapuroteni, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), uye antibody-enzyme fusions, inogadzirwawo uye inotengeswa semushonga mutsva.
Zvinodhaka zvinokonzerwa
Kune varwere, mishonga mitsva yakanangwa inoreva mhedzisiro shoma, zvipatara zvishoma, kuvandudzwa kwehupenyu, kuwedzera kubereka, uye zvakakosha, hupenyu hwakawedzerwa.Asi kukura kwezvinodhaka inguva refu, yakaoma.
Reference
Kohler G, Milstein C. Kuenderera mberi kwetsika dzemaseru akasanganiswa anoburitsa masoja ekudzivirira emuviri wezvakafanotsanangurwa.Nature.1975;256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Therapeutic monoclonal antibody musika.MAbs.2015;7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Rakabudiswa 2015 Jul 14. Inowanikwa pa https://pubmed.ncbi.nlm.nih.gov/26182432/.Yakasvika muna Chikunguru 2020.
Reichert, JM, uye Valge-Archer, VE (2007).Mafambiro ekuvandudza e monoclonal antibody cancer therapeutics.Nat Rev Drug Discov 6, 349-356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Engineered antibody Fc akasiyana ane inowedzeredzwa kuita basa.PNAS 103, 4005–4010.
Professional tekinoroji mainjiniya akazvipira kukutungamira
Zvinoenderana nezvido zvako chaizvo, sarudza inonzwisisika yakazara dhizaini uye kuronga maitiro